Constructing ROS-Responsive Supramolecular Gel with Innate Antibacterial Properties

Bacterial infections, especially antibiotic-resistant bacterial pose a significant threat to human health. Supramolecular gel with innate antibacterial properties is an advanced material for the treatment of which have attracted great attention. Herein, reactive oxygen species (ROS)-responsive supramolecular developed by bottom-up approach based on phenylalanine and hydrazide properties. The structure gelators intermediate products was characterized proton nuclear magnetic resonance (1H NMR) high-resolution mass spectrum (HRMS). results 1H NMR Fourier transform infrared (FT–IR) experiment disclosed that hydrogen bonding π–π stacking force are important self-assembly driving forces gelators. microstructure mechanical were studied Scanning electron microscope (SEM) Rheometer, respectively. An in vitro degradation proved gelator has ROS-responsive drug release further manifested antibiotic-loaded drug-release performances. cytotoxicity showed good biocompatibility could promote cell proliferation. excellent inherent properties, rate against Staphylococcus aureus (S. aureus) Escherichia coli (E. coli) 98.6% 99.1%, as novel agent application prospects treating bacterial-infected wounds preventing development resistance.